A compound present in common foods has demonstrated remarkable effects on longevity, paving the way for new health perspectives.
Phytoene, a colorless carotenoid, has shown significant effects on the lifespan and health of
Caenorhabditis elegans, worms often used as models in biomedical research. The worms experienced an increase in their life expectancy of up to 18.6%.
This effect is thought to be due to a reduction in oxidative stress and protection against amyloid plaques, which are linked to neurodegenerative diseases such as Alzheimer's. Researchers observed a nearly 40% decrease in the damage caused by these plaques.
The study, conducted by researchers from the University of Seville and Kent, tested extracts of microalgae rich in phytoene, as well as the pure compound. All demonstrated similar protective effects on the worms.
Phytoene, although long overlooked due to its lack of color, is widespread in our diet. It can be found in tomatoes, carrots, and red peppers. Its presence in our tissues could also offer protection against UV radiation.
The microalgae used in these experiments, such as
Dunaliella bardawil and
Chlorella sorokiniana, are promising sources of phytoene. They could serve as a basis for the development of new dietary supplements that promote health and longevity.
The findings open the door to further research, notably to better understand the underlying molecular mechanisms. Scientists are now seeking funding to explore these avenues further.
Carotenoids are already well-known for their health benefits. However, these findings raise questions about their exact role, and more specifically, the role of phytoene in the aging process.
How does phytoene protect against oxidative stress?
Oxidative stress is caused by an imbalance between free radicals, unstable molecules, and the antioxidants in the body. This process can damage cells, accelerating aging or the development of diseases.
Phytoene acts as a powerful antioxidant by neutralizing free radicals. By strengthening the body's cellular defense mechanisms, it limits damage caused by these molecules and thus protects tissues, particularly against age-related diseases like Alzheimer's.
Unlike other carotenoids, such as beta-carotene, phytoene is colorless and less studied. However, it has exceptional bioavailability, meaning it is easily absorbed by the body and stored in various tissues, including the skin.
Its antioxidant effects, combined with its protective role against UV radiation, make it a promising candidate for cosmetics and nutrition.
Article author: Cédric DEPOND