Are calorie-free sweeteners as safe as they seem? A new study from the Cleveland Clinic raises concerns about cardiovascular risks associated with a very common sugar substitute: xylitol. Used in many sugar-free candies and toothpastes, this compound could, at high doses, promote the formation of blood clots.
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Led by Dr. Stanley Hazen, this research revealed a correlation between high levels of xylitol and an increased risk of heart attacks and strokes. The findings, published in the
European Heart Journal, are based on an analysis of over 3,000 patients, as well as preclinical tests and a clinical intervention study.
Xylitol, a sugar substitute extracted from birch bark and commonly used in sugar-free products, has seen a significant increase in its use over the past decade. However, researchers stress the need to reassess these sweeteners, particularly those recommended to combat obesity or diabetes.
The researchers found that patients with high levels of xylitol in their plasma had an increased risk of cardiovascular events over three years. Tests showed that xylitol increased platelet activity and thrombosis risk, unlike glucose.
According to Dr. Hazen, while this discovery should not make us discard our toothpaste, it is crucial to be aware that consuming products with high levels of xylitol could increase the risk of thrombotic events.
Ongoing research is essential to evaluate the long-term safety of xylitol. The authors recommend consulting a physician or a certified dietitian for personalized dietary advice.